• Jin Wei, PhD

    2020 Carl W. Gottschalk Research Scholar Grant Recipient
    Jin Wei, PhD

    Jin Wei, PhD

    2020 Carl W. Gottschalk Research Scholar Grant Recipient

    How would you sum up your research in one sentence?

    This project focuses on whether the relaxin receptor 1 at the macula densa plays an important role in control of renal and systemic hemodynamics during normal pregnancy and preeclampsia.

    Provide a brief overview of the research you will conduct with help from the grant.

    The goal of my project is to investigate whether the relaxin-induced renal hemodynamic changes are dependent on macula densa NOS1-mediated TGF mechanism and whether macula densa RXFP1 plays an important role in control of renal and systemic hemodynamics during normal pregnancy and preeclampsia. 

    What inspired you to focus your research in this area?

    Preeclampsia, which is defined as new-onset hypertension and proteinuria after 20 weeks of gestation, affects 3-5% of pregnant women in the United States and is the leading cause of maternal, fetal, and neonatal morbidity and mortality. Currently, there are no specific therapies for preeclampsia except delivery of the placenta and the underlying mechanisms have not been fully elucidated. Thereby, my research focus on the renal mechanism of preeclampsia. 

    What impact do you hope your research will have on patients?

    I hope that findings from this study will lead to novel therapeutic targets and treatment strategies for preeclampsia.

    What are your career goals at the end of the grant period? Five years out? Ten years out?

    My short-term goal is to continue growing my research program that focus on the renal mechanism of preeclampsia. My long-term goal is to become a successful independent investigator in renal research and a well-recognized expert in the field of tubuloglomerular feedback. 

    What has surprised you most about your career?

    I received excellent training in scientific research capabilities and professional skills during my five years of graduate study, which provided me with a strong foundation in both cardio-renal physiology and molecular biology and inspired me to pursue an independent research career.

    What are the major challenges facing nephrology research today?

    We have to keep learning the renal physiology and pathophysiology since the complexity of renal function and structure. We also need to learn the newest technologies since the current technological advancements are so rapid and transformative.

    In one sentence, please describe the importance of having grant funding available through KidneyCure.

    This KidneyCure funding supports me in studying renal mechanism of preeclampsia and provides me the opportunity to pursue my career goals.

    What advice would you give to others to encourage them to apply for this grant funding?

    I strongly encourage all eligible scientists to apply for this grant. This is an excellent grant for supporting early career scientists who pursue their career goals on nephrology research.

    Something you may not know about me is…

    I am a big fan of Houston Rockets.

    In my free time I like to…

    Travel with my family and go fishing.