• Amanda Clark, MD

    2021 Ben J. Lipps Research Fellowship Award
    Amanda Clark, MD

    Amanda Clark, MD

    2021 Ben J. Lipps Research Fellowship Award

    Institution: University of Texas Southwestern

    Project Title: NAD+ Biosynthesis Impairment in Acute Kidney Injury


    How would you sum up your research in one sentence?

    I aim to understand how energy metabolism can be optimized in the kidney to enhance resilience against injury.

    Provide a brief overview of the research you will conduct with help from the grant.

    My work revolves around NAD+, a critical cofactor for energy metabolism. I aim to understand how renal injury affects the synthesis of NAD+, how changes in NAD+ availability affect injury severity, and how NAD+ may be modulated to increase resilience against injury.

    What impact do you hope your research will have on patients?

    Currently, acute kidney injury affects thousands of patients every year. It's costly, and it frequently leads to long-term health complications. There's currently no treatment. I hope to change that.

    What are your career goals at the end of the grant period? Five years out? Ten years out?

    By the end of the grant period, I hope to transition to a career development award continuing to focus optimizing energy metabolism for improved renal health. By 5 years, I'd like to be transitioning to my own lab, and by 10 years, I hope my independent lab is busy and productive. 

    What inspired you to focus your research in this area?

    I've been struck by the paucity of options in treating many kidney diseases, including acute kidney injury. Right now, metabolic therapies are showing substantial promise in that area while technologies to study metabolism are burgeoning. It's an area of research that has the potential to really change clinical practice, and that excites me.

    In one sentence, please describe the importance of having grant funding available through KidneyCure.

    KidneyCure is bridging my research until I am (hopefully) able to obtain a career development grant; this enables me to stay on a research pathway.

    What advice would you give to others to encourage them to apply for this grant funding?

    If you're even considering applying for funding, your work is probably important. Put in the effort to get it funded. Reach out to others for advice and apply! 

    Something you may not know about me is…

    I have a cat with kidney disease! I love to chat about feline nephrology with the veterinary internist. I have discovered some very interesting similarities and differences between human pediatric kidneys and cat kidneys.

    In my free time I like to…

    Work puzzles, go for walks, visit national parks, cuddle my cat.