Titles Sheldon Adler Distinguished Professor of Medicine; Professor of Cell Biology; Professor of Pharmacology and Chemical Biology; Director, Pittsburgh Center for Kidney Research; Chief, Renal-Electrolyte Division, University of Pittsburgh Degrees/Training BS Syracuse University, Syracuse, NY 1973 MD Washington University, St. Louis, MO 1978 MA (honoris causa) University of Pennsylvania, Philadelphia, PA 1997 Internal Medicine Residency: Presbyterian Hospital, New York, NY Nephrology Fellowship: Presbyterian Hospital, New York, NY ASN Service Abstract Selection Committee Member or Section Chair, multiple years; Basic Science Committee 2001-04; Young Investigator Award Committee, 2004-07; Annual Meeting Program Committee, 2007; ASN grant Review Committee, 2022-2028. Societies and Honors American Heart Association (AHA); American Physiological Society (APS); American Society for Biochemistry and Molecular Biology; American Society for Clinical Investigation (elected); American Society of Nephrology; Association of American Physicians (elected); Salt and Water Club. Secretary/Chair, Steering Committee, Epithelial Transport Group, APS, 1999-03; Programming Committee, APS, 1999-03; Co-organizer, 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels, APS, 2011; Member, Cellular and Molecular Biology of the Kidney Study Section, NIH, 2003-07; Alpha Omega Alpha, AHA Clinician-Scientist Award, AHA Established Investigatorship Award; Donald Martin, MD Teaching Service Award; NKF of the Alleghenies Gift of Life Award; NIH MERIT Award; APS Ussing Lecture, 2008; ASN Robert Schrier Lecture, 2009; AHA Donald Seldin Lecture, 2010; Sheldon Adler, MD Chair in Nephrology Research, 2011; Dale Benos Lecture, University of Alabama at Birmingham, 2013; Rogosin Institute Lectureship, Weill Cornell Medical College, 2015; Carl W. Gottschalk Distinguished Lectureship, American Physiological Society, 2015; Hong Memorial Lecture, State University of New York at Buffalo, 2020; Plenary Lecture, Australian and New Zealand Society of Nephrology Annual Meeting, 2022; William Mitch Lecture, Emory University, 2025; Berliner Lecture, Yale University, 2026. Editorial Boards Am J Physiol: Renal Physiol, Ed Board, 1995-2001, 2020-; Associate Editor, 2001-2007; Editor-in-Chief, 2007-2013; J Biol Chem, Ed Board, 2001-2006, 2008-2013; J Clin Invest, Ed Board, 2002-2012; Deputy Editor-in-Chief, Physiological Reports 2012-2017; Editor-in-Chief, Physiological Reports 2018-2022; Editorial Board, JASN, 2017-2023 American Heart Association Service: Cardiorenal Study Section, 1993-97; Review Committee, Southeastern Penn Affiliate, 1994-97; Co-Chair/Chair, Review Committee, Mid-Atlantic Research Consortium 1998-02; Chair, Research Committee, Penn-Delaware Affiliate, 2002-04; Board of Directors, Penn-Delaware Affiliate, 2002-04; Research Committee, AHA National Center, 2003-07; Science Classification Task Force, 2007; Distinguished Scientist Selection Committee, 2010-2012; Established Investigatorship Award Task Force, 2010-2011; Established Investigatorship Award Review Committee, Chair 2011, Member, 2012, 2015, 2017; Council on the Kidney in Cardiovascular Disease Leadership Committee, 2003-07; 2010-2012; Member, AHA Scientific Meetings Initiative Summit, 2014; Reviewer, AHA Strategically Focused Research Network Study Section, 2014; Co-Chair, AHA Bayer Discovery Grant Review Committee, 2017. Board Certification: Internal Medicine Nephrology Research Interests: My group has a longstanding interest in epithelial transport physiology. We are examining mechanisms of ENaC regulation, including the role of proteases in activating ENaC in nephrotic syndrome. We have identified novel functional human ENaC variants and are assessing how these variants affect blood pressure in rodent models and humans. We are also examining the regulation and functional roles of renal K+ secretory channels and mechanosensitive ion channels.